Gene expression is regulated by different kinds of short nucleotide domains. These features can either activate or terminate the transcription process. To predict the signal sites in the 3' gene regions we applied the Hamming-Clustering network (HC) to the poly(A) signal detemination in DNA sequences. This approach employs a technique deriving from the synthesis of digital networks in order to generate prototypes, or rules, which can be directly analyzed or used for the construction of a final neural network
RESULTS
More then 1000 Poly-A signals have been extracted from EMBL database rel. 42 and used to build the training and the test set. The results show the applicability of the Hamming-Clustering method to functional signal prediction.
Software Link:
HCpolya:Hamming Clustering poly-A prediction tool
